Heavy rain has caused significant damage to the rail line between Buxton in Derbyshire and Hazel Grove, Manchester.
Emergency repair work is underway on the route after a flash flood dislodged 6,000t of material earlier in the week.
Network Rail’s “orange army” will replace track and ballast near Middlewood station, Cheshire. An embankment section will also be removed and replaced.
“Nearly two inches of rain in less than two hours is fairly exceptional and the damage it caused to the railway was not insignificant,” said Terry Strickland, area director for Network Rail.
“We understand the impact that this temporary closure will have on passengers and we will be doing all we can, as quickly and safely as we can, so the railway is reopened as soon as possible.”
Material from the railway and neighbouring land will be removed and cutting slope sections repaired.
Network Rail has yet to confirm when the line will reopen.